Nonremodeling Properties of Matrix Metalloproteinases
نویسندگان
چکیده
منابع مشابه
Nonremodeling properties of matrix metalloproteinases: the platelet connection.
Matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), play an important role as mediators of tissue remodeling under physiological and pathological conditions.1 Recently, a number of contributions have shown that in addition to chronic remodeling reactions, MMPs are involved in acute biological reactions associated with discrete cell ...
متن کاملP 88: Matrix Metalloproteinases in Neuroinflammation
Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...
متن کاملMatrix metalloproteinases
What makes an MMP an MMP? They all have a conserved zinc-binding site in their catalytic domain (HEXGHXXGXXH), and the sequence PRCGVPD in the propeptide domain. The cysteine residue serves to anchor the propeptide to the catalytic zinc, suppressing enzymatic activity in a manner that is not unlike a thumb in an open mouth. Release of this interaction results in proteolytic activity. MMPs are a...
متن کاملMatrix Metalloproteinases.
Matrix metalloproteinases are a family of highly regulated peptidases that are collectively responsible for the degradation of extracellular matrix during tissue remodeling. Dysregulated activity has long been implicated in the pathologies of cancer and arthritis, and the number of diseases more recently associated with these enzymes has been increasing. In the past year, new transgenic models ...
متن کاملMatrix metalloproteinases.
Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reprodu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2002
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000021398.28936.1d